PUBLICATIONS 2022

CD8 coreceptor engagement of MR1 enhances antigen responsiveness by human MAIT and other MR1-reactive T cells.

Souter MNT, Awad W, Li S, Pediongco TJ, Meehan BS, Meehan LJ, Tian Z, Zhao Z, Wang H, Nelson A, Le Nours J, Khandokar Y, Praveena T, Wubben J, Lin J, Sullivan LC, Lovrecz GO, Mak JYW, Liu L, Kostenko L, Kedzierska K, Corbett AJ, Fairlie DP, Brooks AG, Gherardin NA, Uldrich AP, Chen Z, Rossjohn J, Godfrey DI, McCluskey J, Pellicci DG, Eckle SBG.

J Exp Med. 2022 Sep 5;219(9):e20210828. doi: 10.1084/jem.20210828. Epub 2022 Aug 26.PMID: 36018322 Free PMC article.

Differential location of NKT and MAIT cells within lymphoid tissue.

Johnson DN, Ruan Z, Petley EV, Devi S, Holz LE, Uldrich AP, Mak JYW, Hor JL, Mueller SN, McCluskey J, Fairlie DP, Darcy PK, Beavis PA, Heath WR, Godfrey DI.

Sci Rep. 2022 Mar 8;12(1):4034. doi: 10.1038/s41598-022-07704-4.PMID: 35260653 Free PMC article.

A specialized tyrosine-based endocytosis signal in MR1 controls antigen presentation to MAIT cells.

Lim HJ, Wubben JM, Garcia CP, Cruz-Gomez S, Deng J, Mak JYW, Hachani A, Anderson RJ, Painter GF, Goyette J, Amarasinghe SL, Ritchie ME, Roquilly A, Fairlie DP, Gaus K, Rossjohn J, Villadangos JA, McWilliam HEG.

J Cell Biol. 2022 Dec 5;221(12):e202110125. doi: 10.1083/jcb.202110125. Epub 2022 Sep 21.PMID: 36129434 Free PMC article.

Helical structure in cyclic peptides: effect of N-methyl amides versus esters.

Wu C, Hoang HN, Hill TA, Lim J, Kok WM, Akondi K, Liu L, Fairlie DP.

Chem Commun (Camb). 2022 Nov 8;58(89):12475-12478. doi: 10.1039/d2cc05092g.PMID: 36274265

QSAR Classification Models for Prediction of Hydroxamate Histone Deacetylase Inhibitor Activity against Malaria Parasites.

Hesping E, Chua MJ, Pflieger M, Qian Y, Dong L, Bachu P, Liu L, Kurz T, Fisher GM, Skinner-Adams TS, Reid RC, Fairlie DP, Andrews KT, Gorse AJP.

ACS Infect Dis. 2022 Jan 14;8(1):106-117. doi: 10.1021/acsinfecdis.1c00355. Epub 2022 Jan 5.PMID: 34985259

Temporal perturbation of histone deacetylase activity reveals a requirement for HDAC1-3 in mesendoderm cell differentiation.

Sinniah E, Wu Z, Shen S, Naval-Sanchez M, Chen X, Lim J, Helfer A, Iyer A, Tng J, Lucke AJ, Reid RC, Redd MA, Nefzger CM, Fairlie DP, Palpant NJ.

Cell Rep. 2022 May 17;39(7):110818. doi: 10.1016/j.celrep.2022.110818.PMID: 35584683 Free article.

Modifying a Hydroxyl Patch in Glucagon-like Peptide 1 Produces Biased Agonists with Unique Signaling Profiles.

Wang P, Hill TA, Mitchell J, Fitzsimmons RL, Xu W, Loh Z, Suen JY, Lim J, Iyer A, Fairlie DP.

J Med Chem. 2022 Sep 8;65(17):11759-11775. doi: 10.1021/acs.jmedchem.2c00653. Epub 2022 Aug 19.PMID: 35984914

Tuning Electrostatic and Hydrophobic Surfaces of Aromatic Rings to Enhance Membrane Association and Cell Uptake of Peptides.

de Araujo AD, Hoang HN, Lim J, Mak JYW, Fairlie DP.

Angew Chem Int Ed Engl. 2022 Jul 18;61(29):e202203995. doi: 10.1002/anie.202203995. Epub 2022 May 25.PMID: 35523729 Free PMC article

Landscaping macrocyclic peptides: stapling hDM2-binding peptides for helicity, protein affinity, proteolytic stability and cell uptake.

de Araujo AD, Lim J, Wu KC, Hoang HN, Nguyen HT, Fairlie DP.

RSC Chem Biol. 2022 May 31;3(7):895-904. doi: 10.1039/d1cb00231g. eCollection 2022 Jul 6.PMID: 35866171 Free PMC article.

The histone deacetylase Hdac7 supports LPS-inducible glycolysis and Il-1β production in murine macrophages via distinct mechanisms.

Ramnath D, Das Gupta K, Wang Y, Abrol R, Curson JEB, Lim J, Reid RC, Mansell A, Blumenthal A, Karunakaran D, Fairlie DP, Sweet MJ.

J Leukoc Biol. 2022 Feb;111(2):327-336. doi: 10.1002/JLB.2MR1021-260R. Epub 2021 Nov 23.PMID: 34811804

Quantitative affinity measurement of small molecule ligand binding to major histocompatibility complex class-I-related protein 1 MR1.

Wang CJH, Awad W, Liu L, Mak JYW, Veerapen N, Illing PT, Purcell AW, Eckle SBG, McCluskey J, Besra GS, Fairlie DP, Rossjohn J, Le Nours J.

J Biol Chem. 2022 Dec;298(12):102714. doi: 10.1016/j.jbc.2022.102714. Epub 2022 Nov 17.PMID: 36403855 Free PMC article.

The balance of interleukin-12 and interleukin-23 determines the bias of MAIT1 versus MAIT17 responses during bacterial infection.

Wang H, Nelson AG, Wang B, Zhao Z, Lim XY, Shi M, Meehan LJ, Jia X, Kedzierska K, Meehan BS, Eckle SB, Souter MN, Pediongco TJ, Mak JY, Fairlie DP, McCluskey J, Wang Z, Corbett AJ, Chen Z.

Immunol Cell Biol. 2022 Aug;100(7):547-561. doi: 10.1111/imcb.12556. Epub 2022 Jun 2.PMID: 35514192 Free PMC article.

Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages.

Tran TT, Mathmann CD, Gatica-Andrades M, Rollo RF, Oelker M, Ljungberg JK, Nguyen TTK, Zamoshnikova A, Kummari LK, Wyer OJK, Irvine KM, Melo-Bolívar J, Gross A, Brown D, Mak JYW, Fairlie DP, Hansford KA, Cooper MA, Giri R, Schreiber V, Joseph SR, Simpson F, Barnett TC, Johansson J, Dankers W, Harris J, Wells TJ, Kapetanovic R, Sweet MJ, Latomanski EA, Newton HJ, Guérillot RJR, Hachani A, Stinear TP, Ong SY, Chandran Y, Hartland EL, Kobe B, Stow JL, Sauer-Eriksson AE, Begun J, Kling JC, Blumenthal A.

PLoS Pathog. 2022 Jan 10;18(1):e1010166. doi: 10.1371/journal.ppat.1010166. eCollection 2022 Jan.PMID: 35007292 Free PMC article.