PUBLICATIONS 2017

Orally Absorbed Cyclic Peptides.

Nielsen DS, Shepherd NE, Xu W, Lucke AJ, Stoermer MJ, Fairlie DP.Chem Rev. 2017 Jun 28;117(12):8094-8128. doi: 10.1021/acs.chemrev.6b00838. Epub 2017 May 25.PMID: 28541045 Review.

Histone deacetylases (HDAC) in physiological and pathological bone remodelling.

Cantley MD, Zannettino ACW, Bartold PM, Fairlie DP, Haynes DR.Bone. 2017 Feb;95:162-174. doi: 10.1016/j.bone.2016.11.028. Epub 2016 Nov 30.PMID: 27913271 Review.

Quinazolinone derivatives as inhibitors of homologous recombinase RAD51.

Ward A, Dong L, Harris JM, Khanna KK, Al-Ejeh F, Fairlie DP, Wiegmans AP, Liu L.Bioorg Med Chem Lett. 2017 Jul 15;27(14):3096-3100. doi: 10.1016/j.bmcl.2017.05.039. Epub 2017 May 15.PMID: 28545975

Biased Signaling by Agonists of Protease Activated Receptor 2.

Jiang Y, Yau MK, Kok WM, Lim J, Wu KC, Liu L, Hill TA, Suen JY, Fairlie DP.ACS Chem Biol. 2017 May 19;12(5):1217-1226. doi: 10.1021/acschembio.6b01088. Epub 2017 Mar 14.PMID: 28169521

Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells.

Keller AN, Eckle SB, Xu W, Liu L, Hughes VA, Mak JY, Meehan BS, Pediongco T, Birkinshaw RW, Chen Z, Wang H, D'Souza C, Kjer-Nielsen L, Gherardin NA, Godfrey DI, Kostenko L, Corbett AJ, Purcell AW, Fairlie DP, McCluskey J, Rossjohn J.Nat Immunol. 2017 Apr;18(4):402-411. doi: 10.1038/ni.3679. Epub 2017 Feb 6.PMID: 28166217

Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells.

Mak JY, Xu W, Reid RC, Corbett AJ, Meehan BS, Wang H, Chen Z, Rossjohn J, McCluskey J, Liu L, Fairlie DP.Nat Commun. 2017 Mar 8;8:14599. doi: 10.1038/ncomms14599.PMID: 28272391 Free PMC article.

The Ribosomal Protein S19 Suppresses Antitumor Immune Responses via the Complement C5a Receptor 1.

Markiewski MM, Vadrevu SK, Sharma SK, Chintala NK, Ghouse S, Cho JH, Fairlie DP, Paterson Y, Astrinidis A, Karbowniczek M.J Immunol. 2017 Apr 1;198(7):2989-2999. doi: 10.4049/jimmunol.1602057. Epub 2017 Feb 22.PMID: 28228558 Free PMC article.

Protease activated receptor 2 controls myelin development, resiliency and repair.

Yoon H, Radulovic M, Walters G, Paulsen AR, Drucker K, Starski P, Wu J, Fairlie DP, Scarisbrick IA.Glia. 2017 Dec;65(12):2070-2086. doi: 10.1002/glia.23215. Epub 2017 Sep 18.PMID: 28921694 Free PMC article.

Europium-Labeled Synthetic C3a Protein as a Novel Fluorescent Probe for Human Complement C3a Receptor.

Dantas de Araujo A, Wu C, Wu KC, Reid RC, Durek T, Lim J, Fairlie DP.Bioconjug Chem. 2017 Jun 21;28(6):1669-1676. doi: 10.1021/acs.bioconjchem.7b00132. Epub 2017 May 31.PMID: 28562031

Mapping transmembrane residues of proteinase activated receptor 2 (PAR2) that influence ligand-modulated calcium signaling.

Suen JY, Adams MN, Lim J, Madala PK, Xu W, Cotterell AJ, He Y, Yau MK, Hooper JD, Fairlie DP.Pharmacol Res. 2017 Mar;117:328-342. doi: 10.1016/j.phrs.2016.12.020. Epub 2016 Dec 16.PMID: 27993717

Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a.

Lohman RJ, Hamidon JK, Reid RC, Rowley JA, Yau MK, Halili MA, Nielsen DS, Lim J, Wu KC, Loh Z, Do A, Suen JY, Iyer A, Fairlie DP.Nat Commun. 2017 Aug 24;8(1):351. doi: 10.1038/s41467-017-00414-w.PMID: 28839129 Free PMC article.

Insecticidal activities of histone deacetylase inhibitors against a dipteran parasite of sheep, Lucilia cuprina.

Bagnall NH, Hines BM, Lucke AJ, Gupta PK, Reid RC, Fairlie DP, Kotze AC.Int J Parasitol Drugs Drug Resist. 2017 Apr;7(1):51-60. doi: 10.1016/j.ijpddr.2017.01.001. Epub 2017 Jan 10.PMID: 28110187 Free PMC article.

Tolyporphin Macrocycles from the Cyanobacterium Tolypothrix nodosa Selectively Bind Copper and Silver and Reverse Multidrug Resistance.

Prinsep MR, Appleton TG, Hanson GR, Lane I, Smith CD, Puddick J, Fairlie DP.Inorg Chem. 2017 May 15;56(10):5577-5585. doi: 10.1021/acs.inorgchem.6b03000. Epub 2017 Feb 27.PMID: 28240882

Effect of clinically approved HDAC inhibitors on Plasmodium, Leishmania and Schistosoma parasite growth.

Chua MJ, Arnold MS, Xu W, Lancelot J, Lamotte S, Späth GF, Prina E, Pierce RJ, Fairlie DP, Skinner-Adams TS, Andrews KT.Int J Parasitol Drugs Drug Resist. 2017 Apr;7(1):42-50. doi: 10.1016/j.ijpddr.2016.12.005. Epub 2016 Dec 23.PMID: 28107750 Free PMC article.

Downsizing Proto-oncogene cFos to Short Helix-Constrained Peptides That Bind Jun.

Baxter D, Perry SR, Hill TA, Kok WM, Zaccai NR, Brady RL, Fairlie DP, Mason JM.ACS Chem Biol. 2017 Aug 18;12(8):2051-2061. doi: 10.1021/acschembio.7b00303. Epub 2017 Jun 21.PMID: 28636317

Mucosal-associated invariant T-cell activation and accumulation after in vivo infection depends on microbial riboflavin synthesis and co-stimulatory signals.

Chen Z, Wang H, D'Souza C, Sun S, Kostenko L, Eckle SB, Meehan BS, Jackson DC, Strugnell RA, Cao H, Wang N, Fairlie DP, Liu L, Godfrey DI, Rossjohn J, McCluskey J, Corbett AJ.Mucosal Immunol. 2017 Jan;10(1):58-68. doi: 10.1038/mi.2016.39. Epub 2016 May 4.PMID: 27143301 Free article.

An HDAC6 Inhibitor Confers Protection and Selectively Inhibits B-Cell Infiltration in DSS-Induced Colitis in Mice.

Do A, Reid RC, Lohman RJ, Sweet MJ, Fairlie DP, Iyer A.J Pharmacol Exp Ther. 2017 Jan;360(1):140-151. doi: 10.1124/jpet.116.236711. Epub 2016 Nov 8.PMID: 27827303

Helixconstraints and amino acid substitution in GLP-1 increase cAMP and insulin secretion but not beta-arrestin 2 signaling.

Plisson F, Hill TA, Mitchell JM, Hoang HN, de Araujo AD, Xu W, Cotterell A, Edmonds DJ, Stanton RV, Derksen DR, Loria PM, Griffith DA, Price DA, Liras S, Fairlie DP.Eur J Med Chem. 2017 Feb 15;127:703-714. doi: 10.1016/j.ejmech.2016.10.044. Epub 2016 Oct 21.PMID: 27823886

Total Synthesis of Mycobacterium tuberculosis Dideoxymycobactin-838 and Stereoisomers: Diverse CD1a-Restricted T Cells Display a Common Hierarchy of Lipopeptide Recognition.

Cheng JM, Liu L, Pellicci DG, Reddiex SJ, Cotton RN, Cheng TY, Young DC, Van Rhijn I, Moody DB, Rossjohn J, Fairlie DP, Godfrey DI, Williams SJ.Chemistry. 2017 Jan 31;23(7):1694-1701. doi: 10.1002/chem.201605287. Epub 2017 Jan 18.PMID: 27925318 Free PMC article.