PUBLICATIONS 2021

Targeting Class IIa HDACs: Insights from Phenotypes and Inhibitors.

Liu L, Dong L, Bourguet E, Fairlie DP.Curr Med Chem. 2021;28(42):8628-8672. doi: 10.2174/ 0929867328666210629160647.PMID: 34212828 Review.

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HDAC7 Inhibition by Phenacetyl and Phenylbenzoyl Hydroxamates.

Mak JYW, Wu KC, Gupta PK, Barbero S, McLaughlin MG, Lucke AJ, Tng J, Lim J, Loh Z, Sweet MJ, Reid RC, Liu L, Fairlie DP.J Med Chem. 2021 Feb 25;64(4):2186-2204. doi: 10.1021/acs.jmedchem.0c01967. Epub 2021 Feb 11.PMID: 33570940

 

 

 

 

 

 

 

 

Taking the Myc out of cancer: toward therapeutic strategies to directly inhibit c-Myc.

Madden SK, de Araujo AD, Gerhardt M, Fairlie DP, Mason JM.Mol Cancer. 2021 Jan 4;20(1):3. doi: 10.1186/s12943-020-01291-6.PMID: 33397405 Free PMC article. Review.

 

 

 

 

 

 

 

MAIT cells regulate NK cell-mediated tumor immunity.

Petley EV, Koay HF, Henderson MA, Sek K, Todd KL, Keam SP, Lai J, House IG, Li J, Zethoven M, Chen AXY, Oliver AJ, Michie J, Freeman AJ, Giuffrida L, Chan JD, Pizzolla A, Mak JYW, McCulloch TR, Souza-Fonseca-Guimaraes F, Kearney CJ, Millen R, Ramsay RG, Huntington ND, McCluskey J, Oliaro J, Fairlie DP, Neeson PJ, Godfrey DI, Beavis PA, Darcy PK.Nat Commun. 2021 Aug 6;12(1):4746. doi: 10.1038/s41467-021-25009-4.PMID: 34362900 Free PMC article.

 

 

 

 

 

 

 

 

Human MAIT cells respond to and suppress HIV-1.

Phetsouphanh C, Phalora P, Hackstein CP, Thornhill J, Munier CML, Meyerowitz J, Murray L, VanVuuren C, Goedhals D, Drexhage L, Moore R, Sattentau QJ, Mak JY, Fairlie DP, Fidler S, Kelleher AD, Frater J, Klenerman P.Elife. 2021 Dec 24;10:e50324. doi: 10.7554/eLife.50324.PMID: 34951583 Free PMC article.

 

 

 

 

 

 

 

Chemical Modulators of Mucosal Associated Invariant T Cells.

Mak JYW, Liu L, Fairlie DP.Acc Chem Res. 2021 Sep 7;54(17):3462-3475. doi: 10.1021/acs.accounts.1c00359. Epub 2021 Aug 20.PMID: 34415738 Free PMC article.

 

 

 

 

 

 

 

Connecting Hydrophobic Surfaces in Cyclic Peptides Increases Membrane Permeability.

Hoang HN, Hill TA, Fairlie DP.Angew Chem Int Ed Engl. 2021 Apr 6;60(15):8385-8390. doi: 10.1002/anie.202012643. Epub 2021 Mar 4.PMID: 33185961

 

 

 

 

 

 

 

Late-Stage Hydrocarbon Conjugation and Cyclisation in Synthetic Peptides and Proteins.

de Araujo AD, Nguyen HT, Fairlie DP.Chembiochem. 2021 May 14;22(10):1784-1789. doi: 10.1002/cbic.202000796. Epub 2021 Mar 15.PMID: 33506598

 

 

 

 

 

 

 

Synthesis of benzoxazole-based vorinostat analogs and their antiproliferative activity.

Mantzourani C, Gkikas D, Kokotos A, Nummela P, Theodoropoulou MA, Wu KC, Fairlie DP, Politis PK, Ristimäki A, Kokotos G.Bioorg Chem. 2021 Sep;114:105132. doi: 10.1016/j.bioorg.2021.105132. Epub 2021 Jun 28.PMID: 34229198

 

 

 

 

 

 

 

Fortified Coiled Coils: Enhancing Mechanical Stability with Lactam or Metal Staples.

López-García P, de Araujo AD, Bergues-Pupo AE, Tunn I, Fairlie DP, Blank KG.Angew Chem Int Ed Engl. 2021 Jan 4;60(1):232-236. doi: 10.1002/anie.202006971. Epub 2020 Oct 29.PMID: 32940968 Free PMC article.

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Identification and Phenotype of MAIT Cells in Cattle and Their Response to Bacterial Infections.

Edmans MD, Connelley TK, Jayaraman S, Vrettou C, Vordermeier M, Mak JYW, Liu L, Fairlie DP, Maze EA, Chrun T, Klenerman P, Eckle SBG, Tchilian E, Benedictus L.Front Immunol. 2021 Mar 11;12:627173. doi: 10.3389/fimmu.2021.627173. eCollection 2021.PMID: 33777010 Free PMC article.

 

 

 

 

 

 

 

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Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection.

Zhao Z, Wang H, Shi M, Zhu T, Pediongco T, Lim XY, Meehan BS, Nelson AG, Fairlie DP, Mak JYW, Eckle SBG, de Lima Moreira M, Tumpach C, Bramhall M, Williams CG, Lee HJ, Haque A, Evrard M, Rossjohn J, McCluskey J, Corbett AJ, Chen Z.Nat Commun. 2021 Jul 16;12(1):4355. doi: 10.1038/s41467-021-24570-2.PMID: 34272362 Free PMC article.

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A Nucleotide Analog Prevents Colitis-Associated Cancer via Beta-Catenin Independently of Inflammation and Autophagy.

Sheng YH, Giri R, Davies J, Schreiber V, Alabbas S, Movva R, He Y, Wu A, Hooper J, McWhinney B, Oancea I, Kijanka G, Hasnain S, Lucke AJ, Fairlie DP, McGuckin MA, Florin TH, Begun J.Cell Mol Gastroenterol Hepatol. 2021;11(1):33-53. doi: 10.1016/j.jcmgh.2020.05.012. Epub 2020 Jun 1.PMID: 32497793 Free PMC article.

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Mechanotransduction activates RhoA in the neighbors of apoptotic epithelial cells to engage apical extrusion.

Duszyc K, Gomez GA, Lagendijk AK, Yau MK, Nanavati BN, Gliddon BL, Hall TE, Verma S, Hogan BM, Pitson SM, Fairlie DP, Parton RG, Yap AS.Curr Biol. 2021 Mar 22;31(6):1326-1336.e5. doi: 10.1016/j.cub.2021.01.003. Epub 2021 Feb 12.PMID: 33581074 Free article.

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PAR2 induces ovarian cancer cell motility by merging three signalling pathways to transactivate EGFR.

Jiang Y, Lim J, Wu KC, Xu W, Suen JY, Fairlie DP.Br J Pharmacol. 2021 Feb;178(4):913-932. doi: 10.1111/bph.15332. Epub 2020 Dec 30.PMID: 33226635 Free article.

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Histone deacetylase inhibitor AR-42 and achiral analogues kill malaria parasites in vitro and in mice.

Chua MJ, Tng J, Hesping E, Fisher GM, Goodman CD, Skinner-Adams T, Do D, Lucke AJ, Reid RC, Fairlie DP, Andrews KT.Int J Parasitol Drugs Drug Resist. 2021 Dec;17:118-127. doi: 10.1016/j.ijpddr.2021.08.006. Epub 2021 Aug 23.PMID: 34560571 Free PMC article.

 

 

 

 

 

 

 

Expression of protease activated receptor-2 is reduced in renal cell carcinoma biopsies and cell lines.

Morais C, Rajandram R, Blakeney JS, Iyer A, Suen JY, Johnson DW, Gobe GC, Fairlie DP, Vesey DA.PLoS One. 2021 Mar 25;16(3):e0248983. doi: 10.1371/journal.pone.0248983. eCollection 2021.PMID: 33765016 Free PMC article.

 

 

 

 

 

 

 

Activation of protease-activated receptor 2 is associated with blood pressure regulation and proteinuria reduction in metabolic syndrome.

Maruyama-Fumoto K, McGuire JJ, Fairlie DP, Shinozuka K, Kagota S.Clin Exp Pharmacol Physiol. 2021 Feb;48(2):211-220. doi: 10.1111/1440-1681.13431. Epub 2020 Nov 21.PMID: 33124085

 

 

 

 

 

 

 

De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex.

Chen KE, Guo Q, Hill TA, Cui Y, Kendall AK, Yang Z, Hall RJ, Healy MD, Sacharz J, Norwood SJ, Fonseka S, Xie B, Reid RC, Leneva N, Parton RG, Ghai R, Stroud DA, Fairlie DP, Suga H, Jackson LP, Teasdale RD, Passioura T, Collins BM.Sci Adv. 2021 Dec 3;7(49):eabg4007. doi: 10.1126/sciadv.abg4007. Epub 2021 Dec 1.PMID: 34851660 Free PMC article.

 

 

 

 

 

 

 

PAR2 Activation on Human Kidney Tubular Epithelial Cells Induces Tissue Factor Synthesis, That Enhances Blood Clotting.

Iyer A, Humphries TLR, Owens EP, Zhao KN, Masci PP, Johnson DW, Nikolic-Paterson D, Gobe GC, Fairlie DP, Vesey DA.Front Physiol. 2021 Mar 10;12:615428. doi: 10.3389/fphys.2021.615428. eCollection 2021.PMID: 33776786 Free PMC article.

 

 

 

 

 

 

 

Mucosal-Associated Invariant T Cell Effector Function Is an Intrinsic Cell Property That Can Be Augmented by the Metabolic Cofactor α-Ketoglutarate.

Howson LJ, Li J, von Borstel A, Barugahare A, Mak JYW, Fairlie DP, McCluskey J, Turner SJ, Davey MS, Rossjohn J.J Immunol. 2021 Apr 1;206(7):1425-1435. doi: 10.4049/jimmunol.2001048. Epub 2021 Feb 17.PMID: 33597151

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PAR2-Induced Tissue Factor Synthesis by Primary Cultures of Human Kidney Tubular Epithelial Cells Is Modified by Glucose Availability.

Humphries TLR, Shen K, Iyer A, Johnson DW, Gobe GC, Nikolic-Paterson D, Fairlie DP, Vesey DA.Int J Mol Sci. 2021 Jul 14;22(14):7532. doi: 10.3390/ijms22147532.PMID: 34299151 Free PMC article.

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