PUBLICATIONS 2018

Chemical Approaches to Modulating Complement-Mediated Diseases.

Iyer A, Xu W, Reid RC, Fairlie DP.J Med Chem. 2018 Apr 26;61(8):3253-3276. doi: 10.1021/acs.jmedchem.7b00882. Epub 2017 Oct 18.PMID: 28977749 Review.

Lysine Deacetylases and Regulated Glycolysis in Macrophages.

Shakespear MR, Iyer A, Cheng CY, Das Gupta K, Singhal A, Fairlie DP, Sweet MJ.Trends Immunol. 2018 Jun;39(6):473-488. doi: 10.1016/j.it.2018.02.009. Epub 2018 Mar 19.PMID: 29567326 Review.

An overview on the identification of MAIT cell antigens.

Kjer-Nielsen L, Corbett AJ, Chen Z, Liu L, Mak JY, Godfrey DI, Rossjohn J, Fairlie DP, McCluskey J, Eckle SB.Immunol Cell Biol. 2018 Jul;96(6):573-587. doi: 10.1111/imcb.12057. Epub 2018 May 15.PMID: 29656544 Review.

MAIT cells protect against pulmonary Legionella longbeachae infection.

Wang H, D'Souza C, Lim XY, Kostenko L, Pediongco TJ, Eckle SBG, Meehan BS, Shi M, Wang N, Li S, Liu L, Mak JYW, Fairlie DP, Iwakura Y, Gunnersen JM, Stent AW, Godfrey DI, Rossjohn J, Westall GP, Kjer-Nielsen L, Strugnell RA, McCluskey J, Corbett AJ, Hinks TSC, Chen Z.Nat Commun. 2018 Aug 22;9(1):3350. doi: 10.1038/s41467-018-05202-8.PMID: 30135490 Free PMC article.

Chemically Diverse Helix-Constrained Peptides Using Selenocysteine Crosslinking.

Dantas de Araujo A, Perry SR, Fairlie DP.Org Lett. 2018 Mar 2;20(5):1453-1456. doi: 10.1021/acs.orglett.8b00233. Epub 2018 Feb 20.PMID: 29461066

Human blood MAIT cell subsets defined using MR1 tetramers.

Gherardin NA, Souter MN, Koay HF, Mangas KM, Seemann T, Stinear TP, Eckle SB, Berzins SP, d'Udekem Y, Konstantinov IE, Fairlie DP, Ritchie DS, Neeson PJ, Pellicci DG, Uldrich AP, McCluskey J, Godfrey DI.Immunol Cell Biol. 2018 May;96(5):507-525. doi: 10.1111/imcb.12021. Epub 2018 Mar 25.PMID: 29437263 Free PMC article.

Hepatic expression profiling identifies steatosis-independent and steatosis-driven advanced fibrosis genes.

Ramnath D, Irvine KM, Lukowski SW, Horsfall LU, Loh Z, Clouston AD, Patel PJ, Fagan KJ, Iyer A, Lampe G, Stow JL, Schroder K, Fairlie DP, Powell JE, Powell EE, Sweet MJ.JCI Insight. 2018 Jul 26;3(14):e120274. doi: 10.1172/jci.insight.120274. eCollection 2018 Jul 26.PMID: 30046009 Free PMC article.

Recipient mucosal-associated invariant T cells control GVHD within the colon.

Varelias A, Bunting MD, Ormerod KL, Koyama M, Olver SD, Straube J, Kuns RD, Robb RJ, Henden AS, Cooper L, Lachner N, Gartlan KH, Lantz O, Kjer-Nielsen L, Mak JY, Fairlie DP, Clouston AD, McCluskey J, Rossjohn J, Lane SW, Hugenholtz P, Hill GR.J Clin Invest. 2018 May 1;128(5):1919-1936. doi: 10.1172/JCI91646. Epub 2018 Apr 9.PMID: 29629900 Free PMC article.

Bicyclic Helical Peptides as Dual Inhibitors Selective for Bcl2A1 and Mcl-1 Proteins.

D de Araujo A, Lim J, Wu KC, Xiang Y, Good AC, Skerlj R, Fairlie DP.J Med Chem. 2018 Apr 12;61(7):2962-2972. doi: 10.1021/acs.jmedchem.8b00010. Epub 2018 Mar 27.PMID: 29584430

Mucosal-Associated Invariant T Cells Augment Immunopathology and Gastritis in Chronic Helicobacter pylori Infection.

D'Souza C, Pediongco T, Wang H, Scheerlinck JY, Kostenko L, Esterbauer R, Stent AW, Eckle SBG, Meehan BS, Strugnell RA, Cao H, Liu L, Mak JYW, Lovrecz G, Lu L, Fairlie DP, Rossjohn J, McCluskey J, Every AL, Chen Z, Corbett AJ.J Immunol. 2018 Mar 1;200(5):1901-1916. doi: 10.4049/jimmunol.1701512. Epub 2018 Jan 29.PMID: 29378910

Complement C3a and C5a receptors promote GVHD by suppressing mitophagy in recipient dendritic cells.

Nguyen H, Kuril S, Bastian D, Kim J, Zhang M, Vaena SG, Dany M, Dai M, Heinrichs JL, Daenthanasanmak A, Iamsawat S, Schutt S, Fu J, Wu Y, Fairlie DP, Atkinson C, Ogretmen B, Tomlinson S, Yu XZ.JCI Insight. 2018 Dec 20;3(24):e121697. doi: 10.1172/jci.insight.121697.PMID: 30568037 Free PMC article.

Enumeration, functional responses and cytotoxic capacity of MAIT cells in newly diagnosed and relapsed multiple myeloma.

Gherardin NA, Loh L, Admojo L, Davenport AJ, Richardson K, Rogers A, Darcy PK, Jenkins MR, Prince HM, Harrison SJ, Quach H, Fairlie DP, Kedzierska K, McCluskey J, Uldrich AP, Neeson PJ, Ritchie DS, Godfrey DI.Sci Rep. 2018 Mar 7;8(1):4159. doi: 10.1038/s41598-018-22130-1.PMID: 29515123 Free PMC article. Clinical Trial.

Glucuronic acid as a helix-inducing linker in short peptides.

Wu C , Hoang HN , Liu L , Fairlie DP .Chem Commun (Camb). 2018 Feb 22;54(17):2162-2165. doi: 10.1039/c7cc09785a.PMID: 29431766

Contiguous hydrophobic and charged surface patches in short helix-constrained peptides drive cell permeability.

Perry SR, Hill TA, de Araujo AD, Hoang HN, Fairlie DP.Org Biomol Chem. 2018 Jan 17;16(3):367-371. doi: 10.1039/c7ob02952g.PMID: 29264603

A Potent Antagonist of Protease-Activated Receptor 2 That Inhibits Multiple Signaling Functions in Human Cancer Cells.

Jiang Y, Yau MK, Lim J, Wu KC, Xu W, Suen JY, Fairlie DP.J Pharmacol Exp Ther. 2018 Feb;364(2):246-257. doi: 10.1124/jpet.117.245027. Epub 2017 Dec 20.PMID: 29263243

Identification of brain metastasis genes and therapeutic evaluation of histone deacetylase inhibitors in a clinically relevant model of breast cancer brain metastasis.

Kim SH, Redvers RP, Chi LH, Ling X, Lucke AJ, Reid RC, Fairlie DP, Martin ACBM, Anderson RL, Denoyer D, Pouliot N.Dis Model Mech. 2018 Jul 6;11(7):DMM034850. doi: 10.1242/dmm.034850.PMID: 29784888 Free PMC article.