PUBLICATIONS 2019

Crystal Structures of Protein-Bound Cyclic Peptides.

Malde AK, Hill TA, Iyer A, Fairlie DP.Chem Rev. 2019 Sep 11;119(17):9861-9914. doi: 10.1021/acs.chemrev.8b00807. Epub 2019 May 2.PMID: 31046237 Review.

Alpha-synuclein structure and Parkinson's disease - lessons and emerging principles.

Meade RM, Fairlie DP, Mason JM.Mol Neurodegener. 2019 Jul 22;14(1):29. doi: 10.1186/s13024-019-0329-1.PMID: 31331359 Free PMC article. Review.

Diverse MR1-restricted T cells in mice and humans.

Koay HF, Gherardin NA, Xu C, Seneviratna R, Zhao Z, Chen Z, Fairlie DP, McCluskey J, Pellicci DG, Uldrich AP, Godfrey DI.Nat Commun. 2019 May 21;10(1):2243. doi: 10.1038/s41467-019-10198-w.PMID: 31113973 Free PMC article.

Characterization of Human Mucosal-associated Invariant T (MAIT) Cells.

Souter MNT, Loh L, Li S, Meehan BS, Gherardin NA, Godfrey DI, Rossjohn J, Fairlie DP, Kedzierska K, Pellicci DG, Chen Z, Kjer-Nielsen L, Corbett AJ, McCluskey J, Eckle SBG.Curr Protoc Immunol. 2019 Dec;127(1):e90. doi: 10.1002/cpim.90.PMID: 31763790

Characterization and Purification of Mouse Mucosal-Associated Invariant T (MAIT) Cells.

Chen Z, Wang H, D'Souza C, Koay HF, Meehan B, Zhao Z, Pediongco T, Shi M, Zhu T, Wang B, Kjer-Nielsen L, Eckle SBG, Rossjohn J, Fairlie DP, Godfrey DI, Strugnell RA, McCluskey J, Corbett AJ.Curr Protoc Immunol. 2019 Dec;127(1):e89. doi: 10.1002/cpim.89.PMID: 31763782

IL-23 costimulates antigen-specific MAIT cell activation and enables vaccination against bacterial infection.

Wang H, Kjer-Nielsen L, Shi M, D'Souza C, Pediongco TJ, Cao H, Kostenko L, Lim XY, Eckle SBG, Meehan BS, Zhu T, Wang B, Zhao Z, Mak JYW, Fairlie DP, Teng MWL, Rossjohn J, Yu D, de St Groth BF, Lovrecz G, Lu L, McCluskey J, Strugnell RA, Corbett AJ, Chen Z.Sci Immunol. 2019 Nov 15;4(41):eaaw0402. doi: 10.1126/sciimmunol.aaw0402.PMID: 31732518

A divergent transcriptional landscape underpins the development and functional branching of MAIT cells.

Koay HF, Su S, Amann-Zalcenstein D, Daley SR, Comerford I, Miosge L, Whyte CE, Konstantinov IE, d'Udekem Y, Baldwin T, Hickey PF, Berzins SP, Mak JYW, Sontani Y, Roots CM, Sidwell T, Kallies A, Chen Z, Nüssing S, Kedzierska K, Mackay LK, McColl SR, Deenick EK, Fairlie DP, McCluskey J, Goodnow CC, Ritchie ME, Belz GT, Naik SH, Pellicci DG, Godfrey DI.Sci Immunol. 2019 Nov 22;4(41):eaay6039. doi: 10.1126/sciimmunol.aay6039.PMID: 31757835 Free PMC article.

A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1.

Le Nours J, Gherardin NA, Ramarathinam SH, Awad W, Wiede F, Gully BS, Khandokar Y, Praveena T, Wubben JM, Sandow JJ, Webb AI, von Borstel A, Rice MT, Redmond SJ, Seneviratna R, Sandoval-Romero ML, Li S, Souter MNT, Eckle SBG, Corbett AJ, Reid HH, Liu L, Fairlie DP, Giles EM, Westall GP, Tothill RW, Davey MS, Berry R, Tiganis T, McCluskey J, Pellicci DG, Purcell AW, Uldrich AP, Godfrey DI, Rossjohn J.Science. 2019 Dec 20;366(6472):1522-1527. doi: 10.1126/science.aav3900.PMID: 31857486

Twists or turns: stabilising alpha vs. beta turns in tetrapeptides.

Hoang HN, Hill TA, Ruiz-Gómez G, Diness F, Mason JM, Wu C, Abbenante G, Shepherd NE, Fairlie DP.Chem Sci. 2019 Oct 3;10(45):10595-10600. doi: 10.1039/c9sc04153b. eCollection 2019 Dec 7.PMID: 32110345 Free PMC article.

Pharmacological inhibition of protease-activated receptor-2 reduces crescent formation in rat nephrotoxic serum nephritis.

Han Y, Tian L, Ma F, Tesch G, Vesey DA, Gobe GC, Lohman RJ, Morais C, Suen JY, Fairlie DP, Nikolic-Paterson DJ.Clin Exp Pharmacol Physiol. 2019 May;46(5):456-464. doi: 10.1111/1440-1681.13077. Epub 2019 Mar 25.PMID: 30811624

Structure-Activity Relationships of Wollamide Cyclic Hexapeptides with Activity against Drug-Resistant and Intracellular Mycobacterium tuberculosis.

Khalil ZG, Hill TA, De Leon Rodriguez LM, Lohman RJ, Hoang HN, Reiling N, Hillemann D, Brimble MA, Fairlie DP, Blumenthal A, Capon RJ.Antimicrob Agents Chemother. 2019 Feb 26;63(3):e01773-18. doi: 10.1128/AAC.01773-18. Print 2019 Mar.PMID: 30602509 Free PMC article.

Oxazole-Benzenesulfonamide Derivatives Inhibit HIV-1 Reverse Transcriptase Interaction with Cellular eEF1A and Reduce Viral Replication.

Rawle DJ, Li D, Wu Z, Wang L, Choong M, Lor M, Reid RC, Fairlie DP, Harris J, Tachedjian G, Poulsen SA, Harrich D.J Virol. 2019 May 29;93(12):e00239-19. doi: 10.1128/JVI.00239-19. Print 2019 Jun 15.PMID: 30918071 Free PMC article.

Mirror image pairs of cyclic hexapeptides have different oral bioavailabilities and metabolic stabilities.

Lohman RJ, Nielsen DS, Kok WM, Hoang HN, Hill TA, Fairlie DP.Chem Commun (Camb). 2019 Nov 18;55(89):13362-13365. doi: 10.1039/c9cc06234c. Epub 2019 Oct 21.PMID: 31631195

Protease-activated receptor 2 does not contribute to renal inflammation or fibrosis in the obstructed kidney.

Ma FY, Han Y, Ozols E, Chew P, Vesey DA, Gobe GC, Morais C, Lohman RJ, Suen JY, Johnson DW, Fairlie DP, Nikolic-Paterson DJ.Nephrology (Carlton). 2019 Sep;24(9):983-991. doi: 10.1111/nep.13635. Epub 2019 Jul 31.PMID: 31314137

A Novel Long-Range n to π* Interaction Secures the Smallest known α-Helix in Water.

Hoang HN, Wu C, Hill TA, Dantas de Araujo A, Bernhardt PV, Liu L, Fairlie DP.Angew Chem Int Ed Engl. 2019 Dec 19;58(52):18873-18877. doi: 10.1002/anie.201911277. Epub 2019 Nov 8.PMID: 31625253

Inhibitors of class I histone deacetylases attenuate thioacetamide-induced liver fibrosis in mice by suppressing hepatic type 2 inflammation.

Loh Z, Fitzsimmons RL, Reid RC, Ramnath D, Clouston A, Gupta PK, Irvine KM, Powell EE, Schroder K, Stow JL, Sweet MJ, Fairlie DP, Iyer A.Br J Pharmacol. 2019 Oct;176(19):3775-3790. doi: 10.1111/bph.14768. Epub 2019 Aug 17.PMID: 31236923 Free PMC article.

MAIT Cells Upregulate α4β7 in Response to Acute Simian Immunodeficiency Virus/Simian HIV Infection but Are Resistant to Peripheral Depletion in Pigtail Macaques.

Juno JA, Wragg KM, Amarasena T, Meehan BS, Mak JYW, Liu L, Fairlie DP, McCluskey J, Eckle SBG, Kent SJ.J Immunol. 2019 Apr 1;202(7):2105-2120. doi: 10.4049/jimmunol.1801405. Epub 2019 Feb 18.PMID: 30777923

Computer Modelling and Synthesis of Deoxy and Monohydroxy Analogues of a Ribitylaminouracil Bacterial Metabolite that Potently Activates Human T Cells.

Ler GJM, Xu W, Mak JYW, Liu L, Bernhardt PV, Fairlie DP.Chemistry. 2019 Dec 5;25(68):15594-15608. doi: 10.1002/chem.201903732. Epub 2019 Nov 7.PMID: 31529537