PUBLICATIONS 2020

Systemic delivery of peptides by the oral route: Formulation and medicinal chemistry approaches.

Brayden DJ, Hill TA, Fairlie DP, Maher S, Mrsny RJ.Adv Drug Deliv Rev. 2020;157:2-36. doi: 10.1016/j.addr.2020.05.007. Epub 2020 May 29.PMID: 32479930 Free article. Review.

Virus-Mediated Suppression of the Antigen Presentation Molecule MR1.

McSharry BP, Samer C, McWilliam HEG, Ashley CL, Yee MB, Steain M, Liu L, Fairlie DP, Kinchington PR, McCluskey J, Abendroth A, Villadangos JA, Rossjohn J, Slobedman B.Cell Rep. 2020 Mar 3;30(9):2948-2962.e4. doi: 10.1016/j.celrep.2020.02.017.PMID: 32130899 Free PMC article.

Protease-activated receptor-2 ligands reveal orthosteric and allosteric mechanisms of receptor inhibition.

Kennedy AJ, Sundström L, Geschwindner S, Poon EKY, Jiang Y, Chen R, Cooke R, Johnstone S, Madin A, Lim J, Liu Q, Lohman RJ, Nordqvist A, Fridén-Saxin M, Yang W, Brown DG, Fairlie DP, Dekker N.Commun Biol. 2020 Dec 17;3(1):782. doi: 10.1038/s42003-020-01504-0.PMID: 33335291 Free PMC article.

Atypical TRAV1-2- T cell receptor recognition of the antigen-presenting molecule MR1.

Awad W, Meermeier EW, Sandoval-Romero ML, Le Nours J, Worley AH, Null MD, Liu L, McCluskey J, Fairlie DP, Lewinsohn DM, Rossjohn J.J Biol Chem. 2020 Oct 16;295(42):14445-14457. doi: 10.1074/jbc.RA120.015292. Epub 2020 Aug 14.PMID: 32817339 Free PMC article.

Potent Thiophene Antagonists of Human Complement C3a Receptor with Anti-Inflammatory Activity.

Rowley JA, Reid RC, Poon EKY, Wu KC, Lim J, Lohman RJ, Hamidon JK, Yau MK, Halili MA, Durek T, Iyer A, Fairlie DP.J Med Chem. 2020 Jan 23;63(2):529-541. doi: 10.1021/acs.jmedchem.9b00927. Epub 2020 Jan 7.PMID: 31910011

The molecular basis underpinning the potency and specificity of MAIT cell antigens.

Awad W, Ler GJM, Xu W, Keller AN, Mak JYW, Lim XY, Liu L, Eckle SBG, Le Nours J, McCluskey J, Corbett AJ, Fairlie DP, Rossjohn J.Nat Immunol. 2020 Apr;21(4):400-411. doi: 10.1038/s41590-020-0616-6. Epub 2020 Mar 2.PMID: 32123373

Lipopolysaccharide promotes Drp1-dependent mitochondrial fission and associated inflammatory responses in macrophages.

Kapetanovic R, Afroz SF, Ramnath D, Lawrence GM, Okada T, Curson JE, de Bruin J, Fairlie DP, Schroder K, St John JC, Blumenthal A, Sweet MJ.Immunol Cell Biol. 2020 Aug;98(7):528-539. doi: 10.1111/imcb.12363. Epub 2020 Jul 20.PMID: 32686869 Free PMC article.

MAIT Cells Promote Tumor Initiation, Growth, and Metastases via Tumor MR1.

Yan J, Allen S, McDonald E, Das I, Mak JYW, Liu L, Fairlie DP, Meehan BS, Chen Z, Corbett AJ, Varelias A, Smyth MJ, Teng MWL.Cancer Discov. 2020 Jan;10(1):124-141. doi: 10.1158/2159-8290.CD-19-0569. Epub 2019 Dec 11.PMID: 31826876

Endoplasmic reticulum chaperones stabilize ligand-receptive MR1 molecules for efficient presentation of metabolite antigens.

McWilliam HEG, Mak JYW, Awad W, Zorkau M, Cruz-Gomez S, Lim HJ, Yan Y, Wormald S, Dagley LF, Eckle SBG, Corbett AJ, Liu H, Li S, Reddiex SJJ, Mintern JD, Liu L, McCluskey J, Rossjohn J, Fairlie DP, Villadangos JA.Proc Natl Acad Sci U S A. 2020 Oct 6;117(40):24974-24985. doi: 10.1073/pnas.2011260117. Epub 2020 Sep 21.PMID: 32958637 Free PMC article.

CXCL16 Stimulates Antigen-Induced MAIT Cell Accumulation but Trafficking During Lung Infection Is CXCR6-Independent.

Yu H, Yang A, Liu L, Mak JYW, Fairlie DP, Cowley S.Front Immunol. 2020 Aug 7;11:1773. doi: 10.3389/fimmu.2020.01773. eCollection 2020.PMID: 32849637 Free PMC article.

Achiral Derivatives of Hydroxamate AR-42 Potently Inhibit Class I HDAC Enzymes and Cancer Cell Proliferation.

Tng J, Lim J, Wu KC, Lucke AJ, Xu W, Reid RC, Fairlie DP.J Med Chem. 2020 Jun 11;63(11):5956-5971. doi: 10.1021/acs.jmedchem.0c00230. Epub 2020 May 21.PMID: 32383881

Class IIa Histone Deacetylases Drive Toll-like Receptor-Inducible Glycolysis and Macrophage Inflammatory Responses via Pyruvate Kinase M2.

Das Gupta K, Shakespear MR, Curson JEB, Murthy AMV, Iyer A, Hodson MP, Ramnath D, Tillu VA, von Pein JB, Reid RC, Tunny K, Hohenhaus DM, Moradi SV, Kelly GM, Kobayashi T, Gunter JH, Stevenson AJ, Xu W, Luo L, Jones A, Johnston WA, Blumenthal A, Alexandrov K, Collins BM, Stow JL, Fairlie DP, Sweet MJ.Cell Rep. 2020 Feb 25;30(8):2712-2728.e8. doi: 10.1016/j.celrep.2020.02.007.PMID: 32101747 Free article.

Human MAIT cell cytolytic effector proteins synergize to overcome carbapenem resistance in Escherichia coli.

Boulouis C, Sia WR, Gulam MY, Teo JQM, Png YT, Phan TK, Mak JYW, Fairlie DP, Poon IKH, Koh TH, Bergman P, Lim CM, Wang LF, Kwa ALH, Sandberg JK, Leeansyah E.PLoS Biol. 2020 Jun 8;18(6):e3000644. doi: 10.1371/journal.pbio.3000644. eCollection 2020 Jun.PMID: 32511236 Free PMC article.

MR1-Restricted T Cells with MAIT-like Characteristics Are Functionally Conserved in the Pteropid Bat Pteropus alecto.

Leeansyah E, Hey YY, Sia WR, Ng JHJ, Gulam MY, Boulouis C, Zhu F, Ahn M, Mak JYW, Fairlie DP, Kwa ALH, Sandberg JK, Wang LF.iScience. 2020 Nov 28;23(12):101876. doi: 10.1016/j.isci.2020.101876. eCollection 2020 Dec 18.PMID: 33344919 Free PMC article.

Artificially induced MAIT cells inhibit M. bovis BCG but not M. tuberculosis during in vivo pulmonary infection.

Yu H, Yang A, Derrick S, Mak JYW, Liu L, Fairlie DP, Cowley S.Sci Rep. 2020 Aug 12;10(1):13579. doi: 10.1038/s41598-020-70615-9.PMID: 32788608 Free PMC article.

Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in MR1.

Howson LJ, Awad W, von Borstel A, Lim HJ, McWilliam HEG, Sandoval-Romero ML, Majumdar S, Hamzeh AR, Andrews TD, McDermott DH, Murphy PM, Le Nours J, Mak JYW, Liu L, Fairlie DP, McCluskey J, Villadangos JA, Cook MC, Turner SJ, Davey MS, Ojaimi S, Rossjohn J.Sci Immunol. 2020 Jul 24;5(49):eabc9492. doi: 10.1126/sciimmunol.abc9492.PMID: 32709702 Free PMC article.