PUBLICATIONS 2016

Review stapling peptides using cysteine crosslinking.

Fairlie DP, Dantas de Araujo A.Biopolymers. 2016 Nov;106(6):843-852. doi: 10.1002/bip.22877.PMID: 27178225 Review.

Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).

Yau MK, Lim J, Liu L, Fairlie DP.Expert Opin Ther Pat. 2016;26(4):471-83. doi: 10.1517/13543776.2016.1154540. Epub 2016 Mar 3.PMID: 26936077 Review.

PAR2 Modulators Derived from GB88.

Yau MK, Liu L, Suen JY, Lim J, Lohman RJ, Jiang Y, Cotterell AJ, Barry GD, Mak JY, Vesey DA, Reid RC, Fairlie DP.ACS Med Chem Lett. 2016 Oct 10;7(12):1179-1184. doi: 10.1021/acsmedchemlett.6b00306. eCollection 2016 Dec 8.PMID: 27994760 Free PMC article.

Histone deacetylases in monocyte/macrophage development, activation and metabolism: refining HDAC targets for inflammatory and infectious diseases.

Das Gupta K, Shakespear MR, Iyer A, Fairlie DP, Sweet MJ.Clin Transl Immunology. 2016 Jan 29;5(1):e62. doi: 10.1038/cti.2015.46. eCollection 2016 Jan.PMID: 26900475 Free PMC article. Review.

Potent Small Agonists of Protease Activated Receptor 2.

Yau MK, Suen JY, Xu W, Lim J, Liu L, Adams MN, He Y, Hooper JD, Reid RC, Fairlie DP.ACS Med Chem Lett. 2015 Nov 30;7(1):105-10. doi: 10.1021/acsmedchemlett.5b00429. eCollection 2016 Jan 14.PMID: 26819675 Free PMC article.

Helix Nucleation by the Smallest Known α-Helix in Water.

Hoang HN, Driver RW, Beyer RL, Hill TA, D de Araujo A, Plisson F, Harrison RS, Goedecke L, Shepherd NE, Fairlie DP.Angew Chem Int Ed Engl. 2016 Jul 11;55(29):8275-9. doi: 10.1002/anie.201602079. Epub 2016 May 25.PMID: 27226426

Membrane-anchored Serine Protease Matriptase Is a Trigger of Pulmonary Fibrogenesis.

Bardou O, Menou A, François C, Duitman JW, von der Thüsen JH, Borie R, Sales KU, Mutze K, Castier Y, Sage E, Liu L, Bugge TH, Fairlie DP, Königshoff M, Crestani B, Borensztajn KS.Am J Respir Crit Care Med. 2016 Apr 15;193(8):847-60. doi: 10.1164/rccm.201502-0299OC.PMID: 26599507 Free PMC article.

Electrophilic Helical Peptides That Bond Covalently, Irreversibly, and Selectively in a Protein-Protein Interaction Site.

de Araujo AD, Lim J, Good AC, Skerlj RT, Fairlie DP.ACS Med Chem Lett. 2016 Nov 15;8(1):22-26. doi: 10.1021/acsmedchemlett.6b00395. eCollection 2017 Jan 12.PMID: 28105269 Free PMC article.

Product release is rate-limiting for catalytic processing by the Dengue virus protease.

Shannon AE, Pedroso MM, Chappell KJ, Watterson D, Liebscher S, Kok WM, Fairlie DP, Schenk G, Young PR.Sci Rep. 2016 Nov 29;6:37539. doi: 10.1038/srep37539.PMID: 27897196 Free PMC article.

The intracellular pathway for the presentation of vitamin B-related antigens by the antigen-presenting molecule MR1.

McWilliam HE, Eckle SB, Theodossis A, Liu L, Chen Z, Wubben JM, Fairlie DP, Strugnell RA, Mintern JD, McCluskey J, Rossjohn J, Villadangos JA.Nat Immunol. 2016 May;17(5):531-7. doi: 10.1038/ni.3416. Epub 2016 Apr 4.PMID: 27043408 Free article.

Differential Anti-inflammatory Activity of HDAC Inhibitors in Human Macrophages and Rat Arthritis.

Lohman RJ, Iyer A, Fairlie TJ, Cotterell A, Gupta P, Reid RC, Vesey DA, Sweet MJ, Fairlie DP.J Pharmacol Exp Ther. 2016 Feb;356(2):387-96. doi: 10.1124/jpet.115.229328. Epub 2015 Dec 10.PMID: 26660228

A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage.

Koay HF, Gherardin NA, Enders A, Loh L, Mackay LK, Almeida CF, Russ BE, Nold-Petry CA, Nold MF, Bedoui S, Chen Z, Corbett AJ, Eckle SB, Meehan B, d'Udekem Y, Konstantinov IE, Lappas M, Liu L, Goodnow CC, Fairlie DP, Rossjohn J, Chong MM, Kedzierska K, Berzins SP, Belz GT, McCluskey J, Uldrich AP, Godfrey DI, Pellicci DG.Nat Immunol. 2016 Nov;17(11):1300-1311. doi: 10.1038/ni.3565. Epub 2016 Sep 26.PMID: 27668799

Benzylamide antagonists of protease activated receptor 2 with anti-inflammatory activity.

Yau MK, Liu L, Lim J, Lohman RJ, Cotterell AJ, Suen JY, Vesey DA, Reid RC, Fairlie DP.Bioorg Med Chem Lett. 2016 Feb 1;26(3):986-991. doi: 10.1016/j.bmcl.2015.12.048. Epub 2015 Dec 17.PMID: 26725028

Diversity of T Cells Restricted by the MHC Class I-Related Molecule MR1 Facilitates Differential Antigen Recognition.

Gherardin NA, Keller AN, Woolley RE, Le Nours J, Ritchie DS, Neeson PJ, Birkinshaw RW, Eckle SBG, Waddington JN, Liu L, Fairlie DP, Uldrich AP, Pellicci DG, McCluskey J, Godfrey DI, Rossjohn J.Immunity. 2016 Jan 19;44(1):32-45. doi: 10.1016/j.immuni.2015.12.005. Epub 2016 Jan 12.PMID: 26795251 Free article.

Human mucosal-associated invariant T cells contribute to antiviral influenza immunity via IL-18-dependent activation.

Loh L, Wang Z, Sant S, Koutsakos M, Jegaskanda S, Corbett AJ, Liu L, Fairlie DP, Crowe J, Rossjohn J, Xu J, Doherty PC, McCluskey J, Kedzierska K.Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):10133-8. doi: 10.1073/pnas.1610750113. Epub 2016 Aug 19.PMID: 27543331 Free PMC article.

Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists.

Seow V, Lim J, Cotterell AJ, Yau MK, Xu W, Lohman RJ, Kok WM, Stoermer MJ, Sweet MJ, Reid RC, Suen JY, Fairlie DP.Sci Rep. 2016 Apr 20;6:24575. doi: 10.1038/srep24575.PMID: 27094554 Free PMC article.

Development of cell-penetrating peptide-based drug leads to inhibit MDMX:p53 and MDM2:p53 interactions.

Philippe G, Huang YH, Cheneval O, Lawrence N, Zhang Z, Fairlie DP, Craik DJ, de Araujo AD, Henriques ST.Biopolymers. 2016 Nov;106(6):853-863. doi: 10.1002/bip.22893.PMID: 27287767

Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease-activated receptor-2.

Lieu T, Savage E, Zhao P, Edgington-Mitchell L, Barlow N, Bron R, Poole DP, McLean P, Lohman RJ, Fairlie DP, Bunnett NW.Br J Pharmacol. 2016 Sep;173(18):2752-65. doi: 10.1111/bph.13554. Epub 2016 Aug 3.PMID: 27423137 Free PMC article.

Simultaneous uncoupled expression and purification of the Dengue virus NS3 protease and NS2B co-factor domain.

Shannon AE, Chappell KJ, Stoermer MJ, Chow SY, Kok WM, Fairlie DP, Young PR.Protein Expr Purif. 2016 Mar;119:124-9. doi: 10.1016/j.pep.2015.11.022. Epub 2015 Dec 2.PMID: 26647367

Downsizing the BAD BH3 peptide to small constrained α-helices with improved ligand efficiency.

Shepherd NE, Harrison RS, Ruiz-Gomez G, Abbenante G, Mason JM, Fairlie DP.Org Biomol Chem. 2016 Nov 22;14(46):10939-10945. doi: 10.1039/c6ob02185a.PMID: 27819377

Truncated Glucagon-like Peptide-1 and Exendin-4 α-Conotoxin pl14a Peptide Chimeras Maintain Potency and α-Helicity and Reveal Interactions Vital for cAMP Signaling in Vitro.

Swedberg JE, Schroeder CI, Mitchell JM, Fairlie DP, Edmonds DJ, Griffith DA, Ruggeri RB, Derksen DR, Loria PM, Price DA, Liras S, Craik DJ.J Biol Chem. 2016 Jul 22;291(30):15778-87. doi: 10.1074/jbc.M116.724542. Epub 2016 May 10.PMID: 27226591 Free PMC article.