PUBLICATIONS 2015

Toward peptide-based inhibitors as therapies for Parkinson's disease.

Mason JM, Fairlie DP.Future Med Chem. 2015;7(16):2103-5. doi: 10.4155/fmc.15.139. Epub 2015 Oct 29.PMID: 26510474 No abstract available.

Nutrient and immune sensing are obligate pathways in metabolism, immunity, and disease.

Iyer A, Brown L, Whitehead JP, Prins JB, Fairlie DP.FASEB J. 2015 Sep;29(9):3612-25. doi: 10.1096/fj.15-271155. Epub 2015 Jun 11.PMID: 26065858 Review.

Recognition of Vitamin B Precursors and Byproducts by Mucosal Associated Invariant T Cells.

Eckle SB, Corbett AJ, Keller AN, Chen Z, Godfrey DI, Liu L, Mak JY, Fairlie DP, Rossjohn J, McCluskey J.J Biol Chem. 2015 Dec 18;290(51):30204-11. doi: 10.1074/jbc.R115.685990. Epub 2015 Oct 14.PMID: 26468291 Free PMC article. Review.

Helix-constrained nociceptin peptides are potent agonists and antagonists of ORL-1 and nociception.

Lohman RJ, Harrison RS, Ruiz-Gómez G, Hoang HN, Shepherd NE, Chow S, Hill TA, Madala PK, Fairlie DP.Vitam Horm. 2015;97:1-55. doi: 10.1016/bs.vh.2014.10.001. Epub 2015 Jan 14.PMID: 25677767 Review.

Potent Small Agonists of Protease Activated Receptor 2.

Yau MK, Suen JY, Xu W, Lim J, Liu L, Adams MN, He Y, Hooper JD, Reid RC, Fairlie DP.ACS Med Chem Lett. 2015 Nov 30;7(1):105-10. doi: 10.1021/acsmedchemlett.5b00429. eCollection 2016 Jan 14.PMID: 26819675 Free PMC article.

Flexibility versus Rigidity for Orally Bioavailable Cyclic Hexapeptides.

Nielsen DS, Lohman RJ, Hoang HN, Hill TA, Jones A, Lucke AJ, Fairlie DP.Chembiochem. 2015 Nov 2;16(16):2289-93. doi: 10.1002/cbic.201500441. Epub 2015 Oct 7.PMID: 26336864

Cyclic alpha-conotoxin peptidomimetic chimeras as potent GLP-1R agonists.

Swedberg JE, Schroeder CI, Mitchell JM, Durek T, Fairlie DP, Edmonds DJ, Griffith DA, Ruggeri RB, Derksen DR, Loria PM, Liras S, Price DA, Craik DJ.Eur J Med Chem. 2015 Oct 20;103:175-84. doi: 10.1016/j.ejmech.2015.08.046. Epub 2015 Aug 29.PMID: 26352676

Repurposing Registered Drugs as Antagonists for Protease-Activated Receptor 2.

Xu W, Lim J, Goh CY, Suen JY, Jiang Y, Yau MK, Wu KC, Liu L, Fairlie DP.J Chem Inf Model. 2015 Oct 26;55(10):2079-84. doi: 10.1021/acs.jcim.5b00500. Epub 2015 Oct 12.PMID: 26445028

Short Hydrophobic Peptides with Cyclic Constraints Are Potent Glucagon-like Peptide-1 Receptor (GLP-1R) Agonists.

Hoang HN, Song K, Hill TA, Derksen DR, Edmonds DJ, Kok WM, Limberakis C, Liras S, Loria PM, Mascitti V, Mathiowetz AM, Mitchell JM, Piotrowski DW, Price DA, Stanton RV, Suen JY, Withka JM, Griffith DA, Fairlie DP.J Med Chem. 2015 May 14;58(9):4080-5. doi: 10.1021/acs.jmedchem.5b00166. Epub 2015 Apr 16.PMID: 25839426

Small molecule inhibitors of disulfide bond formation by the bacterial DsbA-DsbB dual enzyme system.

Halili MA, Bachu P, Lindahl F, Bechara C, Mohanty B, Reid RC, Scanlon MJ, Robinson CV, Fairlie DP, Martin JL.ACS Chem Biol. 2015 Apr 17;10(4):957-64. doi: 10.1021/cb500988r. Epub 2015 Jan 27.PMID: 25603425

Potent complement C3a receptor agonists derived from oxazole amino acids: Structure-activity relationships.

Singh R, Reed AN, Chu P, Scully CC, Yau MK, Suen JY, Durek T, Reid RC, Fairlie DP.Bioorg Med Chem Lett. 2015 Dec 1;25(23):5604-8. doi: 10.1016/j.bmcl.2015.10.038. Epub 2015 Oct 23.PMID: 26522948

Three Homology Models of PAR2 Derived from Different Templates: Application to Antagonist Discovery.

Perry SR, Xu W, Wirija A, Lim J, Yau MK, Stoermer MJ, Lucke AJ, Fairlie DP.J Chem Inf Model. 2015 Jun 22;55(6):1181-91. doi: 10.1021/acs.jcim.5b00087. Epub 2015 May 22.PMID: 26000704

Peptide inhibitors of the Escherichia coli DsbA oxidative machinery essential for bacterial virulence.

Duprez W, Premkumar L, Halili MA, Lindahl F, Reid RC, Fairlie DP, Martin JL.J Med Chem. 2015 Jan 22;58(2):577-87. doi: 10.1021/jm500955s. Epub 2014 Dec 18.PMID: 25470204

Inhibiting histone deacetylase 1 suppresses both inflammation and bone loss in arthritis.

Cantley MD, Fairlie DP, Bartold PM, Marino V, Gupta PK, Haynes DR.Rheumatology (Oxford). 2015 Sep;54(9):1713-23. doi: 10.1093/rheumatology/kev022. Epub 2015 Mar 31.PMID: 25832610

Comparing sixteen scoring functions for predicting biological activities of ligands for protein targets.

Xu W, Lucke AJ, Fairlie DP.J Mol Graph Model. 2015 Apr;57:76-88. doi: 10.1016/j.jmgm.2015.01.009. Epub 2015 Feb 1.PMID: 25682361

Profiling the anti-protozoal activity of anti-cancer HDAC inhibitors against Plasmodium and Trypanosoma parasites.

Engel JA, Jones AJ, Avery VM, Sumanadasa SD, Ng SS, Fairlie DP, Skinner-Adams T, Andrews KT.Int J Parasitol Drugs Drug Resist. 2015 Jun 20;5(3):117-26. doi: 10.1016/j.ijpddr.2015.05.004. eCollection 2015 Dec.PMID: 26199860 Free PMC article.

Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramers.

Rahimpour A, Koay HF, Enders A, Clanchy R, Eckle SB, Meehan B, Chen Z, Whittle B, Liu L, Fairlie DP, Goodnow CC, McCluskey J, Rossjohn J, Uldrich AP, Pellicci DG, Godfrey DI.J Exp Med. 2015 Jun 29;212(7):1095-108. doi: 10.1084/jem.20142110. Epub 2015 Jun 22.PMID: 26101265 Free PMC article.

Virtual Screening of Peptide and Peptidomimetic Fragments Targeted to Inhibit Bacterial Dithiol Oxidase DsbA.

Duprez W, Bachu P, Stoermer MJ, Tay S, McMahon RM, Fairlie DP, Martin JL.PLoS One. 2015 Jul 30;10(7):e0133805. doi: 10.1371/journal.pone.0133805. eCollection 2015.PMID: 26225423 Free PMC article.

Histone Deacetylase Inhibitors Promote Mitochondrial Reactive Oxygen Species Production and Bacterial Clearance by Human Macrophages.

Ariffin JK, das Gupta K, Kapetanovic R, Iyer A, Reid RC, Fairlie DP, Sweet MJ.Antimicrob Agents Chemother. 2015 Dec 28;60(3):1521-9. doi: 10.1128/AAC.01876-15.PMID: 26711769 Free PMC article.

Functional Heterogeneity and Antimycobacterial Effects of Mouse Mucosal-Associated Invariant T Cells Specific for Riboflavin Metabolites.

Sakala IG, Kjer-Nielsen L, Eickhoff CS, Wang X, Blazevic A, Liu L, Fairlie DP, Rossjohn J, McCluskey J, Fremont DH, Hansen TH, Hoft DF.J Immunol. 2015 Jul 15;195(2):587-601. doi: 10.4049/jimmunol.1402545. Epub 2015 Jun 10.PMID: 26063000 Free PMC article.

Facile synthesis of mono- and bis-methylated Fmoc-Dap, -Dab and -Orn amino acids.

Lindahl F, Hoang HN, Fairlie DP, Cooper MA.Chem Commun (Camb). 2015 Mar 14;51(21):4496-8. doi: 10.1039/c4cc09780g.PMID: 25683594

Histone deacetylase enzymes as drug targets for the control of the sheep blowfly, Lucilia cuprina.

Kotze AC, Hines BM, Bagnall NH, Anstead CA, Gupta P, Reid RC, Ruffell AP, Fairlie DP.Int J Parasitol Drugs Drug Resist. 2015 Dec;5(3):201-8. doi: 10.1016/j.ijpddr.2015.09.003. Epub 2015 Oct 9.PMID: 27120067 Free PMC article.