FAIRLIE LAB
IMMUNOLOGY
We aim to better understand the molecular basis of the immune response and study innate and adaptive immunity. Our group works with human neutrophils, macrophages, dendritic cells, mast cells, complement and T cells, investigating their recruitment, differentiation, signalling and modulation in immunity, and especially the effects of novel drug leads on their functions. We are especially interested in complement proteins, GPCRs, T cell receptors, proteases, HDACs, chemokines and cytokines.
Our drugs, after validating targets on human cells and human proteins, are next investigated in rodent models of human diseases and then towards preclinical and clinical studies, either ourselves or with pharma/biotech partners. Understanding how new experimental drugs can stimulate/enhance immune responses or suppress proinflammatory mediators can help in the design and development of effective new therapies to combat a diverse range of important human diseases.
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In 2014 we began two new intiatives. We linked up with physicists, structural biologists and immunologists in Melbourne and Sydney to form the ARC Centre of Excellence in Advanced Molecular Imaging to study the molecular basis of immunity. We also helped form a local Centre for Inflammation and Disease Research in Brisbane.
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