PUBLICATIONS 2024

Sulfated bile acid is a host-derived ligand for MAIT cells.

Ito E, Inuki S, Izumi Y, Takahashi M, Dambayashi Y, Ciacchi L, Awad W, Takeyama A, Shibata K, Mori S, Mak JYW, Fairlie DP, Bamba T, Ishikawa E, Nagae M, Rossjohn J, Yamasaki S.Sci Immunol. 2024 Jan 26;9(91):eade6924. doi: 10.1126/sciimmunol.ade6924. Epub 2024 Jan 26.PMID: 38277465

Dynamic MAIT Cell Recovery after Severe COVID-19 Is Transient with Signs of Heterogeneous Functional Anomalies.

Kammann T, Gorin JB, Parrot T, Gao Y, Ponzetta A, Emgård J, Maleki KT, Sekine T, Rivera-Ballesteros O; Karolinska COVID-19 Study Group; Gredmark-Russ S, Rooyackers O, Skagerberg M, Eriksson LI, Norrby-Teglund A, Mak JYW, Fairlie DP, Björkström NK, Klingström J, Ljunggren HG, Aleman S, Buggert M, Strålin K, Sandberg JK.J Immunol. 2024 Feb 1;212(3):389-396. doi: 10.4049/jimmunol.2300639.PMID: 38117799

Wnt dose escalation during the exit from pluripotency identifies tranilast as a regulator of cardiac mesoderm.

Wu Z, Shen S, Mizikovsky D, Cao Y, Naval-Sanchez M, Tan SZ, Alvarez YD, Sun Y, Chen X, Zhao Q, Kim D, Yang P, Hill TA, Jones A, Fairlie DP, Pébay A, Hewitt AW, Tam PPL, White MD, Nefzger CM, Palpant NJ.Dev Cell. 2024 Feb 9:S1534-5807(24)00039-X. doi: 10.1016/j.devcel.2024.01.019. Online ahead of print.PMID: 38354738

Potent Immunomodulators Developed from an Unstable Bacterial Metabolite of Vitamin B2 Biosynthesis

Mak JWY, Rivero RJD, Hoang HN, Lim XY, Deng J, McWilliam HEG, Villadangos JA, McCluskey J, Corbett AJ, Fairlie DP.

Angew Chem Int Ed Engl 2024 Apr 28:e202400632.

doi: 10.1002/anie.202400632. Online ahead of print.

Mouse mucosal-associated invariant T cell receptor recognition of MR1 presenting the vitamin B metabolite, 5-(2-oxopropylideneamino)-6-d-ribitylaminouracil

Ciacchi L, Mak JWY, Le JP, Fairlie DP, McCluskey J, Corbett AJ, Rossjohn J, Awad W.

J Biol Chem 2024 Mar 25;300(5):107229.

doi: 10.1016/j.jbc.2024.107229. Online ahead of print.

MAIT cell-MR1 reactivity is highly conserved across multiple divergent species

Edmans MD, Connelley TK, Morgan S, Pediongco TJ, Jayaraman S, Juno JA, Meehan BS, Dewar PM, Maze EA, Roos EO, Paudyal B, Mak JYW, Liu L, Fairlie DP, Wang H, Corbett AJ, McCluskey J, Benedictus L, Tchilian E, Klenerman P, Eckle SBG.

J Biol Chem 2024 May 3:107338.

doi: 10.1016/j.jbc.2024.107338. Online ahead of print.

Protease-activated receptor 2: a promising therapeutic target for women's cancers

Shah H, Fairlie DP, Lim J.

JPET May 6, 2024, JPET-MR-2024-002176; DOI: https://doi.org/10.1124/jpet.124.002176

Abstract TP320: The Novel Potent Complement C3a Receptor (C3aR) Antagonist JR14a Confers Robust Neuroprotection in Stroke

Ahmad S, Contreras J, Bhatia K, Fairlie DP, Waters MF, Ducruet AF.

Stroke, 1 Feb 2024;55:ATP320