PUBLICATIONS 2024

Sulfated bile acid is a host-derived ligand for MAIT cells.

Ito E, Inuki S, Izumi Y, Takahashi M, Dambayashi Y, Ciacchi L, Awad W, Takeyama A, Shibata K, Mori S, Mak JYW, Fairlie DP, Bamba T, Ishikawa E, Nagae M, Rossjohn J, Yamasaki S.

Sci Immunol. 2024 Jan 26;9(91):eade6924. doi: 10.1126/sciimmunol.ade6924. Epub 2024 Jan 26.PMID: 38277465

Dynamic MAIT Cell Recovery after Severe COVID-19 Is Transient with Signs of Heterogeneous Functional Anomalies.

Kammann T, Gorin JB, Parrot T, Gao Y, Ponzetta A, Emgård J, Maleki KT, Sekine T, Rivera-Ballesteros O; Karolinska COVID-19 Study Group; Gredmark-Russ S, Rooyackers O, Skagerberg M, Eriksson LI, Norrby-Teglund A, Mak JYW, Fairlie DP, Björkström NK, Klingström J, Ljunggren HG, Aleman S, Buggert M, Strålin K, Sandberg JK.

J Immunol. 2024 Feb 1;212(3):389-396. doi: 10.4049/jimmunol.2300639.PMID: 38117799

Wnt dose escalation during the exit from pluripotency identifies tranilast as a regulator of cardiac mesoderm.

Wu Z, Shen S, Mizikovsky D, Cao Y, Naval-Sanchez M, Tan SZ, Alvarez YD, Sun Y, Chen X, Zhao Q, Kim D, Yang P, Hill TA, Jones A, Fairlie DP, Pébay A, Hewitt AW, Tam PPL, White MD, Nefzger CM, Palpant NJ.

Dev Cell. 2024 Feb 9:S1534-5807(24)00039-X. doi: 10.1016/j.devcel.2024.01.019. Online ahead of print.PMID: 38354738

Potent Immunomodulators Developed from an Unstable Bacterial Metabolite of Vitamin B2 Biosynthesis

Mak JWY, Rivero RJD, Hoang HN, Lim XY, Deng J, McWilliam HEG, Villadangos JA, McCluskey J, Corbett AJ, Fairlie DP.

Angew Chem Int Ed Engl 2024 Apr 28:e202400632.

doi: 10.1002/anie.202400632. Online ahead of print.

Mouse mucosal-associated invariant T cell receptor recognition of MR1 presenting the vitamin B metabolite, 5-(2-oxopropylideneamino)-6-d-ribitylaminouracil

Ciacchi L, Mak JWY, Le JP, Fairlie DP, McCluskey J, Corbett AJ, Rossjohn J, Awad W.

J Biol Chem 2024 Mar 25;300(5):107229.

doi: 10.1016/j.jbc.2024.107229. Online ahead of print.

MAIT cell-MR1 reactivity is highly conserved across multiple divergent species

Edmans MD, Connelley TK, Morgan S, Pediongco TJ, Jayaraman S, Juno JA, Meehan BS, Dewar PM, Maze EA, Roos EO, Paudyal B, Mak JYW, Liu L, Fairlie DP, Wang H, Corbett AJ, McCluskey J, Benedictus L, Tchilian E, Klenerman P, Eckle SBG.

J Biol Chem 2024 May 3:107338.

doi: 10.1016/j.jbc.2024.107338. Online ahead of print.

Abstract TP320: The Novel Potent Complement C3a Receptor (C3aR) Antagonist JR14a Confers Robust Neuroprotection in Stroke

Ahmad S, Contreras J, Bhatia K, Fairlie DP, Waters MF, Ducruet AF.

Stroke, 1 Feb 2024;55:ATP320

MAIT cell activation and recruitment in inflammation and tissue damage in acute appendicitis

Zheng Y, Han F, Wu Z, Wang B, Chen X, Boulouis C, Jiang Y, Ho A, He D, Si WR, Mak JYW, Fairlie DP, Wang L-F, Sandberg JK, Lobie PE, Ma S, Leeansyah E.

Sci Adv. 2024 Jun 14;10 (24):eadn6331.

Varicella Zoster Virus disrupts MAIT cell polyfunctional effector responses

Purohit SK, Stern L, Corbett AJ, Mak JYW, Fairlie DP, Slobedman B, Abendroth A.

PLOS Pathogens 2024 Aug 7;20(8):e1012372.

A novel inhibitor of class IIa histone deacetylases attenuates collagen-induced arthritis

Poon EK, Liu L, Wu KC, Lim J, Sweet MJ, Lohman RJ, Iyer A, Fairlie DP.

Br J Pharmacol. 2024 181, 4804-4821. Sep 2. doi: 10.1111/bph.17306.

MAIT cell heterogeneity across paired human tissues reveals specialization of distinct regulatory and enhanced effector profiles.

Kammann T, Cai C, Sekine T, Mouchtaridi E, Boulouis C, Nilsén V, .. Mak JYW, Fairlie DP, Leeansyah E, Michaelsson J, Marquardt N, Mjösberg J, Jorns C, Buggert M, Sandberg JK.

Sci Immunol 2024, 9, eadn2362.

Selective regulation of IFN-γ and IL-4 co-producing unconventional T cells by purinergic signaling.

Xu C, Obers A, Qin M, Brandli A, Wong J, Huang X, Clatch A, Fayed A, Starkey G, D'Costa R, Gordon CL, Mak JYW, Fairlie DP, Beattie L, Mackay LK, Godfrey DI, Koay HF.

J Exp Med 2024, 221, e20240354.

MAIT cell plasticity enables functional adaptation that drives antibacterial immune protection.

Wang H, Souter MNT, de Lima Moreira M, Li S, Zhou Y, Nelson AG, Yu J, Meehan LJ, Meehan BS, Eckle SBG, Lee HJ, Schröder J, Haque A, Mak JYW, Fairlie DP, McCluskey J, Wang Z, Chen Z, Corbett AJ.

Sci Immunol 2024, 9, eadp9841.

MR1 presents vitamin B6-related compounds for recognition by MR1-reactive T cells.

McInerney MP, Awad W, Souter MNT, Kang Y, Wang CJH, Chan Yew Poa K, Abdelaal MR, Le NH, Shepherd CM, McNeice C, Meehan LJ, Nelson AG, Raynes JM, Mak JYW, McCluskey J, Chen Z, Ang CS, Fairlie DP, Le Nours J, Illing PT, Rossjohn J, Purcell AW.

Proc Natl Acad Sci U S A 2024, 121, e2414792121.